2022 Jan 20;386(3):294-295. doi: 10.1056/NEJMc2118255. On . 2016 May;150(5):1147-1159.e5. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 Lanifibranor Placebo Stable, Moderate increase, Increase Stable, Increase CI: Confidence interval Screening EOT-20 0 20 40 60 m e a n a . The percentage of patients with a decrease of at least 2 points in SAF-A score was significantly higher in patients taking the 1200-mg dose of lanifibranor (55%), but not the 800-mg dose (48%), than among those taking placebo (33%). During the NATIVE Phase IIb trial, 21% and 31% of patients in the lanifibranor 800mg/day and 1200mg/day dose groups respectively achieved the Phase III primary composite endpoint after only 24 . N Engl J Med. Epub 2020 Nov 13. Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPAR, PPAR, and PPAR, respectively, for transactivation activity. Semaglutide, but not . "Lanifibranor induced a histologic improvement despite this weight gain, which could be explained by the role of adipose tissue dysfunction rather than overweight per se in the . Although regression of fibrosis can be indirectly accomplished with long-term therapy to control disease activity, the combination of therapy to control disease activity and fibrogenesis, the goals of which are reflected in the composite [secondary] endpoint could have a stronger and faster effect on disease progression, explained the researchers. In this phase 2b, double-blind, randomized, placebo-controlled trial, patients with noncirrhotic, highly active NASH were randomly assigned in a 1:1:1 ratio to receive 1200 mg or 800 mg of lanifibranor or placebo once daily for 24 weeks. RRs of 2.2 and 1.7 for the respective 1,200- and 800-mg doses. Mouse models of nonalcoholic steatohepatitis and their application to Front Pharmacol. Copyright 2021 Massachusetts Medical Society. Examples of Lanifibranor in a sentence. Documented causes of chronic liver disease other than NASH, Histologically documented liver cirrhosis (fibrosis stage F4), History or current diagnosis of hepatocellular carcinoma HCC, Positive human immunodeficiency virus (HIV) serology, Abnormal synthetic liver function as defined by Screening central laboratory evaluation, Haemoglobin <110 g/L (11 g/dL) for females and <120 g/L (12 g/dL) for males, Patient currently receiving any approved treatment for NASH or obesity, Current or recent history (<5 years) of significant alcohol consumption, History of heart failure with reduced left ventricular ejection fraction (LVEF), Atrial fibrillation requiring anticoagulation, Participation in any clinical trial investigational medicinal product/device within 3 months from Screening or 5 half-lives from Screening, whichever is longer, Concomitant treatment with PPAR-alpha agonists (fibrates). Four of the peripheral oedema cases were deemed lanifibranor-related, with one being severe. Comparisons between the lanifibranor and placebo arms yielded RRs of 2.2 and 1.7 for the respective 1,200- and 800-mg doses. Lanifibranor KOL Breakfast - DocsLib Current status and challenges in the drug treatment for fibrotic The primary endpoint of a reduction of at least two points in SAF-A . Lanifibranor, a first-in-class pan-peroxisome proliferator-activated receptor (PPAR) agonist, has shown promise in the treatment of nonalcoholic steatohepatitis (NASH), an aggressive form of nonalcoholic fatty liver disease with few treatment options. Contrary to hepatitis C [which is] caused by a single aetiologic agent, NASH is a multifactorial, complex metabolic disorder that forms part of a systemic disease. Hepatoprotective effects of semaglutide, lanifibranor and dietary Moreover, lanifibranor-treated TAA-rats showed decreased ascites, improved LSEC and HSC phenotypes, ameliorated hepatic microvascular function, reduced hepatic inflammation, and significant fibrosis regression (-32%; p = 0.020). Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have been reported as a novel worldwide epidemic, very often associated with . Secondary end points included resolution of NASH and regression of fibrosis. : 927961-18- 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. Structure for Lanifibranor (DB14801) . Overall, most AEs with lanifibranor were mild-to-moderate in severity, and discontinuation rates were low (4 percent and 5 percent in the respective lanifibranor 1,200- and 800-mg arms). Uncontrolled hypertension at Screening (values >160/100 mm Hg). Tsuchida et al. [PDF] Design, Synthesis, and Evaluation of a Novel Series of Indole Inventiva announces the design of LEGEND, a Phase IIa combination trial Please enable it to take advantage of the complete set of features! The pan-PPAR agonist lanifibranor reduces development of lung fibrosis Currently 55, the public has been comparing Gillibrand's physical transformation from when she was young and now. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Novel Drug Lanifibranor Promising for NASH, The Future of the Restaurant Industry with QR Technology, Stress busting tips to live a happier life. PDF Safety Data Sheet - MedchemExpress.com Liver enzyme levels decreased and the levels of most lipid, inflammatory, and fibrosis biomarkers improved in the lanifibranor groups. Diarrhea, nausea, peripheral edema, anemia, and weight gain occurred more frequently with lanifibranor than with placebo. The LEGEND trial is a proof-of-concept Phase IIa clinical trial to evaluate the safety and efficacy of lanifibranor in combination with the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (Jardiance 1) in patients with non-alcoholic steatohepatitis (NASH) and type 2 diabetes (T2D) The trial will be conducted in several sites in the United States and Europe with a treatment . eCollection 2022. Alternative Names: IVA-337. No effect on kidney function or markers of bone turnover was observed. These phase 2b results with lanifibranor are very welcoming and encouraging but should be interpreted with caution, she said. The .gov means its official. So, here's how Kirsten Gillibrand is as of 2022. A total of 2000 patients will be randomised to receive lanifibranor (800 mg/day) or lanifibranor (1200 mg/day), or matching placebo, employing a 1:1:1 randomisation scheme, respectively, without interruption between Part 1 and Part 2. However, the mice exhibit comparable body weight to those fed a control diet and significantly lower than those fed with HFD, suggesting CCl 4 masks HFD-induced weight gain (Kubota et al. Exendin4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration. Type Small Molecule Groups Investigational Structure. Similar to other insulin sensitizers, patients receiving lanifibranor had weight gain during treatment (2.6%-3.1% from baseline). 1 a composite secondary endpoint that is unique to this trial (35 percent vs 9 percent; The researchers attributed the weight gain to improved adipose tissue function, as reflected by the increases in serum adiponectin level with both lanifibranor 1,200 and 800 mg (, ). with lanifibranor were mild-to-moderate in severity, and discontinuation rates were low (4 percent and 5 percent in the respective lanifibranor 1,200- and 800-mg arms). Among patients treated with Lanifibranor, weight gain and peripheral edema occurred more frequently compared to placebo. Lanifibranor (IVA337) is a moderately potent and well-balanced pan-PPAR agonist (Boubia et al., 2018 ). . Lanifibranor tackles both metabolic drivers of the disease, most notably the adipose tissue dysfunction, as well as the mechanisms of inflammation and fibrogenesis inside the liver. Analysts tip Inventiva's lanifibranor as NASH blockbuster - pharmaphorum Epub 2022 Jul 6. RR, 4.0 and 25 percent vs 9 percent; RR, 2.6, respectively). Methods: lanifibranor in patients with noncirrhotic NASH with se-vere disease activity. Weight reduction surgeries are being done for that purpose when appropriate. The percentage of patients who had a decrease of at least 2 points in the SAF-A score without worsening of fibrosis was significantly higher among those who received the 1200-mg dose, but not among those who received the 800-mg dose, of lanifibranor than among those who received placebo (1200-mg dose vs. placebo, 55% vs. 33%, P = 0.007; 800-mg dose vs. placebo, 48% vs. 33%, P = 0.07). Nat Rev Gastroenterol Hepatol. Inventiva and Sino Biopharm announce licensing and collaboration Three poster presentations showing the beneficial effects of lanifibranor on markers of cardiometabolic health in patients with non-cirrhotic NASH fibrosis independent of weight gain observed.the . Lanifibranor | 99%(HPLC) | PARP agonist | AdooQ anagement of NASH is an unmet clinical need, said the researchers. Administration of high (100 mg/kg) doses of Lanifibranor results in reduced body weight compare with vehicle controls (p<0.05; Lanifibranor at 100 mg/kg vs vehicle). 2022 Jan 20;386(3):294. doi: 10.1056/NEJMc2118255. Gastrointestinal side effects were also more common in the treatment group. Reactive Oxygen Species and Oxidative Stress in the Pathogenesis of MAFLD. 2021 Mar 25;384(12):1113-1124. doi: 10.1056/NEJMoa2028395. There is a large need for drugs that prevent the development of this disease and its complications, Wakim-Fleming, who was not involved in the study, told Medscape Medical News. Pan-PPAR agonist lanifibranor improves portal hypertension and - PubMed Inventiva announces three scientific presentations at the EASL - Yahoo! Lanifibranor is a novel pan-PPAR (peroxisome proliferator-activated receptors) agonist. Efficacy of peroxisome proliferator-activated receptor agonists, glucagon-like peptide-1 receptor agonists, or sodium-glucose cotransporter-2 inhibitors for treatment of non-alcoholic fatty liver disease: a systematic review. Yoneda M, Kobayashi T, Asako N, Iwaki M, Saito S, Nakajima A. Hepatobiliary Surg Nutr. There were also more lanifibranor vs placebo recipients who had improvement in fibrosis stage of. 2022 Jan 20;386(3):295. doi: 10.1056/NEJMc2118255. The overall knowledge and encyclopedia of Lanifibranor covering characteristics, safety, usage, MSDS/SDS and more. Lanifibranor is a peroxisome proliferator-activated receptor (PPAR) agonist that works by activating 3 PPAR isoforms: PPAR, PPAR, and PPAR. *The above data is based on the productmolecular weight 434.91. FOIA Catalog No. At 6 months, compared with the placebo arm, the percentage of participants with a reduction of. Before ClinicalTrials.gov Identifier: NCT04849728, Interventional z o.o. Nonetheless, the patient with the severe case recovered after drug discontinuation for 12 days, without reoccurrence after treatment resumption. TG mice treated with higher dose lanifibranor had significant protection from lung fibrosis compared with those treated with vehicle or lower dose lanifibranor. One of the trending United States Senators, Kirsten Gillibrand is being talked about not just for her advocacy but also for her weight gain. Wakim-Fleming disclosed no relevant financial relationships. [N Engl J Med 2021;385:1547-1558]. Drug Formulation: This drug may be formulated in DMSO. LANIFIBRANOR (IVA-337) is a pan peroxisome proliferator-activated receptor (PPAR) agonist with EC50s of 1.5, 0.87 and 0.21 uM for human PPARa, PPARb and PPARg, respectively. Therapeutic approaches for non-alcoholic steatohepatitis 2 points in the SAF-A score without worsening of fibrosis was significantly higher in the lanifibranor 1,200-mg arm (55 percent vs 33 percent; 2022 Oct 28;10(5):947-954. doi: 10.14218/JCTH.2022.00052. - Debrecen, Debrecen, Hajdu-Bihar County, Hungary, 4025, Debreceni Egyetem Klinikai Kzpont Kenzy Gyula Campus, Dl-pesti Centrumkrhz - Orszgos Hematolgiai s Infektolgiai Intzet, Jerusalem, Jerusalem District, Israel, 9103102, Jerusalem, Jerusalem District, Israel, 9112001, Nahariya, Northern District, Israel, 22100, Be'er Sheva, Southern District, Israel, 84101, San Giovanni Rotondo, Foggia, Italy, 71013, Centro de Investigacin y Gastroenterologa, Cuauhtmoc, Ciudad De Mxico, Mexico, 06700, Contact: Alma Laura Ladron De Guevara Cetina, Doctor, Contact: Laura Esthela Cisneros Garza, Doctor, Hospital Universitario Doctor Jos Eleuterio Gonzalez, Amsterdam Universitair Medische Centra - Vrije Universiteit Medisch Centrum, Amsterdam, Noord-Holland, Netherlands, 1081 HV, Tilburg, North Brabant, Netherlands, 5000 LC, Rotterdam, Zuid-Holland, Netherlands, 3015 GD, Niepubliczny Zaklad Opieki Zdrowotnej Centrum Badan Klinicznych, Contact: Orkwiszewska-Nalewajko Anna, Doctor, Mysowice, Silesian Voivodeship, Poland, 41-400, Contact: Magdalena Olszanecka-Glinianowicz, Doctor, Synexus Polska Sp. Most simply, it might be due to taking in more calories through food and drink than your body needs, or not expending enough energy to use it up. the beneficial effects of lanifibranor on markers of cardiometabolic health in patients with non-cirrhotic NASH fibrosis independent of weight gain observed. 2022 Jun;11(3):481-484. doi: 10.21037/hbsn-21-569. risk ratio [RR], 1.7; p=0.007), but not in the lanifibranor 800-mg arm (48 percent vs 33 percent; RR, Phase II data underscores lanifibranor potential for NASH A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis. Front Med (Lausanne). Resolution of NASH without worsening fibrosis a key secondary end point also occurred more often in patients taking lanifibranor. Administration of high (100 mg/kg) doses of Lanifibranor results in reduced body weight compare with vehicle controls (p<0.05; Lanifibranor at 100 mg/kg vs vehicle). Both low and high doses of Lanifibranor cause a significant decrease of collagenous matrix deposition. Elafibranor was well tolerated, without weight gain, without cardiac events, and with a mild and reversible increase in serum creatinine. Bentley P, Calder I, Elcombe C, Grasso P, Stringer D, Wiegand HJ. Both low and high doses of Lanifibranor cause a significant decrease of collagenous matrix deposition. 2022 Jun;11(3):433-435. doi: 10.21037/hbsn-21-579. PMC ). Similar Structures. The side effects of lanifibranor in this trial were seen in 4% of the patients, notably concerning are the severe adverse events and the weight gain.. Lanifibranor is a pan-PPAR (peroxisome proliferator-activated receptor) agonist that modulates key metabolic, inflammatory, and fibrogenic pathways in the pathogenesis of NASH. About lanifibranor . These included resolution of NASH without worsening of fibrosis (49% and 39%, respectively, vs 22%), improvement in fibrosis stage of at least 1 without worsening of NASH (48% and 34%, respectively, vs 29%), and resolution of NASH plus improvement in fibrosis stage of at least 1 (35% and 25%, respectively, vs 9%). Inventiva Pharma funded the study and paid for professional writing assistance and copyediting. 2022 Oct 28;10(5):939-946. doi: 10.14218/JCTH.2022.00067. MOL SDF 3D-SDF PDB SMILES InChI. Substance Class Chemical After this period of treatment we analyzed the hepatic and systemic hemodynamics . The study was published online October 20 in The New England Journal of Medicine. Inventiva announces three scientific presentations at the There was also an improvement in the lipid profile. Price : $50 *. 8600 Rockville Pike How to pronounce Lanifibranor | HowToPronounce.com N Engl J Med. NASH has superseded hepatitis C as the main cause of cirrhosis and main reason for liver transplantation, said. For more news, follow Medscape on Facebook, Twitter, Instagram, YouTube, and LinkedIn. The complex pathophysiology of NASH may require targeting multiple pathways rather than a single pathway for successful treatment, said the researchers. Copyright 2022 MIMS Pte Ltd. All rights reserved. Why Should I Register and Submit Results? Newsome PN, Buchholtz K, Cusi K, Linder M, Okanoue T, Ratziu V, Sanyal AJ, Sejling AS, Harrison SA; NN9931-4296 Investigators. Lanifibranor | Biocompare Is it necessary to target lipid metabolism in different organs for Pregnancy and Metabolic-associated Fatty Liver Disease: A Clinical Update. Lanifibranor is currently evaluated in a pivotal Phase III trial in NASHInventiva will receive a $12 million upfront, $5. Fouda S, Vennikandam MM, Pappachan JM, Fernandez CJ. Reached for comment, Jamile Wakim-Fleming, MD, who directs the fatty liver disease program at the Cleveland Clinic in Ohio, said NASH is a rising etiology of liver disease, cirrhosis, and its complications, and it affects about 25% of the general population in the United States and worldwide.. There were also more lanifibranor vs placebo recipients who had improvement in fibrosis stage of Disclaimer, National Library of Medicine By continuing to browse you agree to the storing of cookies on your device. These findings support further assessment of lanifibranor in phase 3 trials. Lanifibranor induced a histologic improvement despite this weight gain, which could be explained by the role of adipose tissue dysfunction rather than overweight per se in the pathophysiology of NASH, and by a shift from visceral to metabolically healthy subcutaneous adipose tissue, a finding that was noted with other PPAR agonists.. Future phase III trials of longer duration with larger cohorts shall provide more in-depth evaluations of the long-term efficacy and safety of lanifibranor in in this setting. Get to learn about Lanifibranor. Results: Lanifibranor | C19H15ClN2O4S2 - PubChem Disclosure forms for authors and editorialist are available at NEJM.org. Thus, it remains debatable whether the benefits of lanifibranor on NASH histology are mainly related to its PPAR- effects, and more research is needed to clarify this issue [ 45 - 48 ]. Lanifibranor in NASH - a Pan-PPAR Agonist - Dibesity A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in N Engl J Med. Three patients from each. The primary end point was a decrease of at least 2 points in the SAF-A score (the activity part of the Steatosis, Activity, Fibrosis [SAF] scoring system that incorporates scores for ballooning and inflammation) without worsening of fibrosis; SAF-A scores range from 0 to 4, with higher scores indicating more-severe disease activity. HOW SOCIAL IS YOUR SOCIAL MEDIA STRATEGY? Three poster presentations showing . Sven M F, Pierre B, Manal F A, Quentin M A, Elisabetta B, Vlad R, Philippe HM, Bruno S, Jean-Louis J, Pierre B, Jean-Louis A. Contemp Clin Trials. Contrary to hepatitis C [which is] caused by a single aetiologic agent, NASH is a multifactorial, complex metabolic disorder that forms part of a systemic disease. The most common adverse events (AEs) with both lanifibranor doses were diarrhoea (22 percent), fatigue (17 percent), nausea (18 percent), weight gain (18 percent), and peripheral oedema (14 percent). Lanifibranor - an overview | ScienceDirect Topics Lanifibranor is an orally-available small molecule that acts to induce anti-fibrotic, anti-inflammatory as well as beneficial metabolic changes in the body by activating each of the three PPAR isoforms, known as PPAR, PPAR and PPAR. The New England Journal of Medicine publishes the results of the NATIVE Phase IIb clinical trial with lanifibranor in NASH 20 October 2021 . Lanifibranor induced a histologic improvement despite this weight gain, which could be explained by the role of adipose tissue dysfunction rather than overweight per se in the pathophysiology of NASH, and by a shift from visceral to metabolically healthy subcutaneous adipose tissue, a finding that was noted with other PPAR agonists.. NASH is a complex disease in terms of pathophysiology, and different targets need to be tackled simultaneously to have a substantial impact on the disease, Francque told Medscape Medical News. Pan-PPAR Agonist 'Promising' for NASH Patients | MedPage Today Similarly, there was no difference between placebo and lanifibranor treatments in slowing the overall progression of the condition, or in improving lung function. Wang Y, Parlevliet ET, Geerling JJ, et al. Lancet Gastroenterol Hepatol. Affiliations. The chemical Lanifibranor has a designated molecular formula of C19H15ClN2O4S2 and a molecular weight of 434.909 g/mol. and was sustained after a total of 8 weeks (26%) and 12 weeks (24%) of treatment, respectively. Harrington WW, Britt CS, Wilson JG, et al. The most common side effects were diarrhea, nausea, peripheral edema, anemia, and weight gain, which occurred more commonly with lanifibranor. Weight Gain an Issue? Lanifibranor Definition | Law Insider Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months). Epub 2022 May 26. Part 2 To assess the effect of lanifibranor compared to placebo on delaying NASH disease progression measured by a composite endpoint that includes progression to cirrhosis, liver-related clinical outcome events, or all-cause death. N Engl J Med. 2 points in the SAF-A score without worsening of fibrosis was significantly higher in the lanifibranor 1,200-mg arm (55 percent vs 33 percent; p=0.007), but not in the lanifibranor 800-mg arm (48 percent vs 33 percent; RR, The fraction of patients who achieved NASH resolution without worsening of fibrosis was also greater in the lanifibranor 1,200-mg (49 percent) and 800-mg arms (39 percent) vs the placebo arm (22 percent). Lanifibranor - C19H15ClN2O4S2 - Bertin Bioreagent However, lanifibranor recipients gained an average of about 5 pounds, which Francque suggested might reflect a shift from visceral abdominal fat to subcutaneous fat under the skin. NASH has superseded hepatitis C as the main cause of cirrhosis and main reason for liver transplantation, said The results favored both the 1200-mg and 800-mg doses of lanifibranor over placebo on several secondary end points. The risk ratio for a response to 800-mg lanifibranor vs placebo was 1.5 (95% CI, 1.0 2.1; P = .07). The primary end point was a decrease of at least 2 points in the Steatosis, Activity, Fibrosis (SAF)-Activity score, without worsening of fibrosis. 2013). There is currently no FDA-approved . Download . Results demonstrate that activation of Peroxisome proliferator-activated . 1 a composite secondary endpoint that is unique to this trial (35 percent vs 9 percent; Bookshelf Data from Phase 2b trial of GENFIT's Elafibranor published in Lanifibranor looks like a highly efficacious drugwith a good safety profile, and if confirmed in phase 3, this would be a major breakthrough, as we currently havent seen any drug that has a significant effect on both steatohepatitis and fibrosis and this in the timeframe of 6 months, Francque told Medscape Medical News. Females of childbearing potential must practice a consistent and proper use of highly effective method of contraception throughout the study and for 1 month after treatment discontinuation. 900 NASH patients with moderate to advanced fibrosis are expected to join the study. A Randomized, Controlled Trial of the Pan-PPAR Agonist Lanifibranor in 2022 Oct 10;9:974182. doi: 10.3389/fmed.2022.974182. Talk with your doctor and family members or friends about deciding to join a study. 2022 Oct 13;13:958428. doi: 10.3389/fphar.2022.958428. Shelf Life: >2 years if stored properly. J Clin Transl Hepatol. Lanifibranor - Inventiva Pharma Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPAR, PPAR, and PPAR, respectively, for transactivation activity. Adverse events (AEs) in the lanifibranor groups were mild to moderate, with nausea, diarrhea, peripheral edema, anemia, and weight gain occurring more frequently. Inventiva and Sino Biopharm announce licensing and collaboration Genetic and Rare Diseases Information Center, U.S. Department of Health and Human Services. J Clin Transl Hepatol. Sven Francque said that weight gain plateaued after treatment stopped. Weight gain was around 3kg in the highest dose of Lanifibranor compared with 5 kg previously observed with Pioglitazone probably due to the activation of PPAR- that increases energy expenditure and fatty acid oxidation. Rates of peripheral oedema were around 6% to 8.5%, lower than the 14%-23% reported for another PPAR drug, pioglitazone, although lanifibranor was also associated with similar levels of weight gain . Rachid TL, PennadeCarvalho A, Bringhenti I, Aguila MB, MandarimdeLacerda CA, SouzaMello V. Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from dietinduced male obese mice. and transmitted securely. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Inventiva announces the design of LEGEND, a Phase IIa combination trial with lanifibranor and SGLT2 inhibitor empagliflozin in patients with NASH and type 2 diabetes 27 October 2021. BangBerthelsen CH, Holm TL, Pyke C, et al. Novel Drug Lanifibranor Promising for NASH - Medscape Epub 2022 Jan 12. In a phase 2b trial, the pan-PPAR agonist lanifibranor showed promise for patients with active non-alcoholic steatohepatitis (NASH). Lanifibranor Gets Fast Track Status for Non-Alcoholic Steatohepatitis Lanifibranor, also known as IVA-337, is a peroxisome proliferator-activated receptors (PPAR) agonist. Weight Average: 434.91 Monoisotopic: 434.016177 Chemical Formula C 19 H 15 ClN 2 O 4 S 2 Synonyms.
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